P2X7 receptor expression increased in microglia during status epilepticus, at times when responses to anticonvulsants were reduced. Mice overexpressing P2X7 receptors were unresponsive to several anticonvulsants (lorazepam, midazolam, phenytoin and carbamazepine) during status epilepticus. Severity of status epilepticus was compared in animals with overexpressing or knock-out of the P2X7 receptor, after inflammatory priming by pre-injection of bacterial lipopolysaccharide (LPS) and in mice treated with P2X7 receptor-targeting and anti-inflammatory drugs. Status epilepticus was induced via a unilateral microinjection of kainic acid into the amygdala in adult mice. Here, we have determined the contribution of the ATP-gated P2X7 receptor, previously linked to inflammation and increased hyperexcitability, to drug-refractory status epilepticus and its therapeutic potential. Increasing evidence suggests neuroinflammation contributes to the development of drug-refractoriness during status epilepticus. Beamer attended Los Gatos High School, Wheaton Academy, DePaul University, California State University, Fresno and Wheaton College.įor the Pittsburgh Post-Gazette's biography of Todd Beamer, click here.Refractory status epilepticus is a clinical emergency associated with high mortality and morbidity. Wheaton College also has a building named There is also a high school (Todd Beamer High School) in Federal Way, WA, named after Beamer. They burst into the cockpit and fought with the terrorists over the controls for the plane.Ī post office in Cranbury, New Jersey, was named after him. Recording) were that the passengers on Flight 93 did not cause the plane to crash intentionally. Though it was a widely-held belief that the passengers crashed the airliner in an attempt to save the lives of others on the ground, the 9/11 Commission's findings (based on the 'black box' cockpit According to Jefferson,īeamer's last audible words were 'Are you guys ready? Let's roll.' This term would later become the war cry for those fighting Al Qaeda in Afghanistan. Later, he told the operator that some of the plane's passengers were planning 'jump on' the hijackers. Turn in a southeasterly direction, a move that had him briefly panicking. He was also on the phone when the plane made its Passenger was killed and, later, that a flight attendant had told him the pilot and co-pilot had been forced from the cockpit and may have been wounded. Beamer tried to placeĬredit card call through a phone located on the back of a plane seat but was routed to a customer-service representative instead, who passed him on to supervisor Lisa Jefferson. Todd and other passengers had been in communication with people via in-plane and cell phones and learned that the World Trade Center had been attacked using hijacked airplanes. nearly four months after her father's death. Survived by his wife, Lisa Beamer, two sons, David and Drew, and a daughter, Morgan Kay, who was born on Janu.

He died at age 32 in the Septemattacks on board United Airlines Flight 93.

Todd Beamer, who resided in Cranbury, New Jersey, was an account manager for the Oracle Corporation.

Morgan beamer